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Thus, ferroptosis can significantly alter the metastatic potential of cancer cells by affecting processes such as cytoskeletal remodeling and angiogenesis, offering new perspectives for cancer therapy

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The authors also found that FLNA is required for SSTR2 mediated inhibition of cell survival, and the molecular mechanism involves a competition of FLNA with p85, the regulatory subunit of PI3K, for direct binding to SSTR2

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